Latest GMI Study Abstracts

Latest GMI Study Abstracts

Ursolic acid may be helpful for the treatment of autoimmune thyroiditis.

Article Published Date : Jan 15, 2021
Study Type : In Vitro Study
Additional Links
Substances : Ursolic Acid : CK(132) : AC(91)
Diseases : Autoimmune Thyroiditis : CK(149) : AC(19)
Pharmacological Actions : Anti-Inflammatory Agents : CK(12461) : AC(4729), MicroRNA modulator : CK(264) : AC(145)

P-coumaric acid and ursolic acid from Corni fructus attenuated β-amyloid(25-35)-induced toxicity.

Article Published Date : May 27, 2014
Study Type : In Vitro Study
Additional Links
Substances : P-Coumaric Acid : CK(2) : AC(2), Ursolic Acid : CK(132) : AC(91)
Diseases : Alzheimer's Disease : CK(2442) : AC(871)
Pharmacological Actions : Anti-Apoptotic : CK(1620) : AC(932), Anti-Inflammatory Agents : CK(12461) : AC(4729), Cyclooxygenase 2 Inhibitors : CK(1114) : AC(645), Neuroprotective Agents : CK(6374) : AC(2801), NF-kappaB Inhibitor : CK(2446) : AC(1436)
Additional Keywords : Plant Extracts : CK(11762) : AC(4236)

Antiangiogenic effects of p-coumaric acid in human endothelial cells.

Article Published Date : Feb 28, 2013
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : P-Coumaric Acid : CK(2) : AC(2)
Diseases : Cancers: All : CK(22165) : AC(7896)
Pharmacological Actions : Anti-Angiogenic : CK(282) : AC(192), Chemopreventive : CK(4220) : AC(1326)

P-coumaric acid, a dietary polyphenol ameliorates inflammation and curtails cartilage and bone erosion in the rheumatoid arthritis rat model.

Article Published Date : Sep 09, 2017
Study Type : Animal Study
Additional Links
Substances : P-Coumaric Acid : CK(2) : AC(2)
Diseases : Arthritis : CK(2971) : AC(597), Rheumatoid Arthritis : CK(1140) : AC(209)
Pharmacological Actions : Anti-Inflammatory Agents : CK(12461) : AC(4729), Chondroprotective : CK(1) : AC(1)

Drug-induced anti-inflammatory response in A549 cells, as detected by Raman spectroscopy: a comparative analysis of the actions of dexamethasone and p-coumaric acid.

Article Published Date : Feb 24, 2019
Study Type : In Vitro Study
Additional Links
Substances : P-Coumaric Acid : CK(2) : AC(2)
Diseases : Chronic Obstructive Pulmonary Disease : CK(386) : AC(58), Inflammation : CK(6531) : AC(1986)
Pharmacological Actions : Anti-Inflammatory Agents : CK(12461) : AC(4729)

P-coumaric acid modulates glucose and lipid metabolism via AMP-activated protein kinase in L6 skeletal muscle cells.

Article Published Date : Mar 21, 2013
Study Type : In Vitro Study
Additional Links
Substances : P-Coumaric Acid : CK(2) : AC(2)
Diseases : Hyperglycemia : CK(967) : AC(262), Hyperlipidemia : CK(1076) : AC(272)
Pharmacological Actions : Hypoglycemic Agents : CK(3297) : AC(841), Hypolipidemic : CK(3189) : AC(707)

P-coumaric acid is capable of causing inhibitory effects on the activities of enzymes, associated with oxidative stress-induced erectile dysfunction.

Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Substances : P-Coumaric Acid : CK(2) : AC(2)
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin : CK(296) : AC(149), Erectile Dysfunction : CK(340) : AC(54), Oxidative Stress : CK(6519) : AC(2436)
Pharmacological Actions : Antioxidants : CK(14410) : AC(5758), Enzyme Inhibitors : CK(602) : AC(312)

p-Coumaric acid attenuates alcohol exposed hepatic injury through MAPKs, apoptosis and Nrf2 signaling in experimental models.

Article Published Date : Apr 24, 2020
Study Type : Animal Study
Additional Links
Substances : P-Coumaric Acid : CK(2) : AC(2)
Diseases : Alcohol Toxicity : CK(660) : AC(249), Alcoholic Liver Disease : CK(152) : AC(61), Lipid Peroxidation : CK(1178) : AC(476)
Pharmacological Actions : Anti-Apoptotic : CK(1620) : AC(932), Antioxidants : CK(14410) : AC(5758), Hepatoprotective : CK(3182) : AC(1418), Nrf2 activation : CK(177) : AC(86)

Results describe a protective effect of P-coumaric acid against doxorubicin-induced nephrotoxicity.

Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : P-Coumaric Acid : CK(2) : AC(2)
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin : CK(296) : AC(149), Inflammation : CK(6531) : AC(1986), Lipid Peroxidation : CK(1178) : AC(476), Oxidative Stress : CK(6519) : AC(2436)
Pharmacological Actions : Anti-Inflammatory Agents : CK(12461) : AC(4729), Antioxidants : CK(14410) : AC(5758), Catalase Up-Regulation : CK(118) : AC(42), Chemoprotective Agents : CK(356) : AC(146), Interleukin-1 beta downregulation : CK(1743) : AC(868), Superoxide Dismutase Up-regulation : CK(1039) : AC(415), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(4357) : AC(1763)

Electroacupuncture can effectively reverse atherosclerosis.

Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Diseases : Atherosclerosis : CK(1017) : AC(315)
Pharmacological Actions : Gastrointestinal Agents : CK(268) : AC(41)

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